International Journal of Technology and Applied Science

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Formulation and Evaluation of Capsules of using Taagra Extract for Anxiety

Author(s) Divya Arjun Ahire, Neha Tongire
Country India
Abstract Anxiety disorders are predominantly managed using synthetic medications, such as benzodiazepines and SSRIs, which often carry risks of severe side effects, tolerance, and chemical dependency. Valeriana wallichii (Tagara), a highly revered herb in traditional Ayurvedic medicine, offers a scientifically backed natural alternative. Its primary active constituent, valerenic acid, gently modulates GABA-A receptors and inhibits GABA transaminase to induce a safe, calming effect. However, translating the raw hydroalcoholic extract of Tagara into a modern pharmaceutical dosage form is significantly challenged by its highly hygroscopic nature, poor powder flowability, pungent odor, and bitter taste.
This research aimed to systematically formulate, engineer, and evaluate a standardized oral hard gelatin capsule utilizing Tagara root extract to overcome these physical limitations. A 70:30 ethanol-to-water extraction yielded 13.70% w/w of concentrated crude extract, which was validated through phytochemical screening for essential secondary metabolites, including flavonoids, alkaloids, and saponins.
The engineered, free-flowing blend was encapsulated into Size 0 hard gelatin shells. Subsequent pharmacopeial quality control evaluations confirmed the batch met all official standards. The capsules exhibited exceptional weight uniformity (maximum deviation of ±2.74%), rapid in-vitro disintegration (12 minutes and 45 seconds), and a highly efficient dissolution profile, releasing over 85% of the active therapeutic compounds within 45 minutes. Accelerated stability testing (40°C at 75% RH for 12 weeks) further confirmed the formulation's mechanical and physical integrity. Ultimately, this study successfully transformed a challenging botanical extract into a stable, uniform, and patient-compliant pharmaceutical dosage form for the clinical management of anxiety.
 
Keywords Valeriana wallichii, Tagara extract, anxiety disorders, valerenic acid, hard gelatin capsules, hydroalcoholic extraction, GABA-A receptor modulation, pre-formulation engineering, pharmacopeial evaluation.
Field Medical / Pharmacy
Published In Volume 17, Issue 5, May 2026
Published On 2026-05-30
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