International Journal of Technology and Applied Science

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Formulation And Evaluation Of Aceclofenac Dispersible Tablet

Author(s) Mr. Sumeet Sahebrao Pawar, Mrs. Bhagyashali Baheti
Country India
Abstract Aceclofenac dispersible tablets were formulated and evaluated to improve patient compliance and provide rapid drug release for the treatment of pain and inflammation. The present study aimed to prepare dispersible tablets of aceclofenac by the direct compression method using suitable superdisintegrants and excipients. Different formulations were developed using ingredients such as microcrystalline cellulose, sodium starch glycolate, mannitol, talc, and magnesium stearate in varying concentrations to achieve rapid disintegration and acceptable tablet characteristics. The prepared tablets were evaluated for pre-compression parameters including angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio to determine flow properties of the powder blend. Post-compression evaluation tests such as hardness, thickness, friability, weight variation, drug content uniformity, wetting time, dispersion time, disintegration time, and in-vitro dissolution studies were also carried out according to pharmacopeial standards. The results showed that all formulations possessed satisfactory physical properties with good mechanical strength and acceptable friability. Among the formulations, the optimized batch exhibited rapid disintegration, improved drug release, and good stability. The in-vitro dissolution study demonstrated faster release of aceclofenac from dispersible tablets compared to conventional tablets, indicating enhanced bioavailability and quick therapeutic action. The study concluded that aceclofenac dispersible tablets can be successfully prepared by direct compression using suitable superdisintegrants. The formulation provides better patient convenience, faster onset of action, and improved compliance, especially for pediatric and geriatric patients who experience difficulty in swallowing conventional tablets.
Keywords fast dispersible tablet, aceclofenac, Magnesium stearate ,starch, disintegration time, dissolution.
Field Medical / Pharmacy
Published In Volume 17, Issue 5, May 2026
Published On 2026-05-23
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