International Journal of Technology and Applied Science

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Formulation and Evaluation of Polyherbal ORS Enriched with Immunomodulatory and Anti-diarrheal Phytoconstituents

Author(s) Ms. Vijaya Dnyaneshwar Thombre, Mrs. Bhagyashali Baheti
Country India
Abstract Diarrheal diseases are among the leading causes of dehydration, electrolyte imbalance, and gastrointestinal complications, particularly in children and elderly individuals. Conventional Oral Rehydration Solution (ORS) effectively restores fluid and electrolyte balance but lacks antimicrobial, antioxidant, and immunomodulatory properties. The present study aimed to formulate and evaluate a polyherbal ORS enriched with medicinal plant extracts possessing anti-diarrheal and immune-enhancing activities. Herbal extracts of Ocimum sanctum, Zingiber officinale, Phyllanthus emblica, and Mentha piperita were incorporated into a WHO-based ORS formulation in different concentrations to prepare three formulations (F1, F2, and F3). The prepared formulations were evaluated for organoleptic characteristics, pH, phytochemical constituents, antimicrobial activity, and stability. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, and phenolic compounds. Antimicrobial activity was assessed against Escherichia coli using the agar well diffusion method. The formulations exhibited significant antibacterial activity with zones of inhibition of 10 mm, 15 mm, and 17 mm for F1, F2, and F3 respectively. Stability studies showed no significant changes in color, odor, precipitation, or pH during storage. Among all formulations, F2 containing 20 mL polyherbal extract demonstrated optimum pH, acceptable taste, good stability, and significant antimicrobial activity, making it the optimized formulation. The study concluded that the developed polyherbal ORS can serve as a safe, stable, economical, and multifunctional therapeutic formulation providing rehydration along with antimicrobial, antioxidant, digestive, and gut-protective benefits for the management of diarrhea-associated dehydration.
Keywords Polyherbal, Immunomodulatory, ORS, Diarrhea, Dehydration
Field Medical / Pharmacy
Published In Volume 17, Issue 5, May 2026
Published On 2026-05-23
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