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Development and Evaluation of Herbal Anti-Acne Gel Containing Neem and Aloe Vera with QA & QC Parameters

Author(s) Ms. Sonali Prakash Patil, Mrs. Bhagyashali Baheti
Country India
Abstract The present research work focused on the development and evaluation of a herbal anti-acne gel containing Neem (Azadirachta indica) and Aloe vera (Aloe barbadensis Miller) using various Quality Assurance (QA) and Quality Control (QC) parameters. Acne vulgaris is one of the most common chronic inflammatory skin disorders caused by excessive sebum secretion, bacterial infection, inflammation, and blockage of sebaceous follicles. Conventional anti-acne preparations often produce adverse effects such as skin irritation, dryness, redness, and microbial resistance during prolonged use. Therefore, herbal formulations are increasingly preferred because of their safety, effectiveness, affordability, and minimal side effects. Neem possesses significant antibacterial, anti-inflammatory, antifungal, antioxidant, and antiseptic properties due to the presence of bioactive constituents such as nimbidin, azadirachtin, flavonoids, and tannins. Aloe vera provides moisturizing, soothing, wound-healing, and skin-regenerating effects that improve skin hydration and reduce irritation associated with acne lesions. In the present study, three formulations of herbal anti-acne gel (F1, F2, and F3) were prepared using different concentrations of Neem extract and Aloe vera gel with Carbopol 940 as the gelling agent. The prepared formulations were evaluated for various physicochemical and quality control parameters including colour, appearance, pH, viscosity, spreadability, extrudability, washability, antimicrobial activity, phytochemical screening, microbial limit test, and stability studies. The pH of all formulations was found within the acceptable skin-compatible range of 5.5–7.0. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, and saponins responsible for therapeutic activity. Among all formulations, batch F2 exhibited the most desirable characteristics with optimum viscosity, excellent spreadability, superior extrudability, enhanced antimicrobial activity, suitable pH, highly stable nature, and better patient acceptability. Stability studies revealed no significant changes in colour, consistency, pH, or homogeneity during storage. The antimicrobial evaluation demonstrated effective inhibition of acne-causing microorganisms. The synergistic combination of Neem and Aloe vera provided antibacterial, anti-inflammatory, antioxidant, moisturizing, and healing effects, making the formulation effective for topical acne management. Based on the overall findings, it can be concluded that the formulated herbal anti-acne gel is safe, stable, effective, economical, and suitable for topical application. Formulation F2 was selected as the optimized batch due to its superior physicochemical properties, stability, and therapeutic effectiveness. The study suggests that the herbal anti-acne gel containing Neem and Aloe vera may serve as a promising natural alternative to synthetic anti-acne preparations with reduced side effects and improved patient compliance.
Keywords Herbal, Quality Assurance, Quality Cntrol, Antimicrobial, Patient compliance
Field Medical / Pharmacy
Published In Volume 17, Issue 5, May 2026
Published On 2026-05-23
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